Meningeal Inflammation Increases Artemether Concentrations in Cerebrospinal Fluid in Papua New Guinean Children Treated with Intramuscular Artemether
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چکیده
منابع مشابه
Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria.
There are sparse published data relating to the pharmacokinetic properties of artemether, lumefantrine, and their active metabolites in children, especially desbutyl-lumefantrine. We studied 13 Papua New Guinean children aged 5 to 10 years with uncomplicated malaria who received the six recommended doses of artemether (1.7 mg/kg of body weight) plus lumefantrine (10 mg/kg), given with fat over ...
متن کاملPopulation pharmacokinetics of artemether , lumefantrine and their 1 respective metabolites in Papua New Guinean children with uncomplicated 2 malaria
Population pharmacokinetics of artemether, lumefantrine and their 1 respective metabolites in Papua New Guinean children with uncomplicated 2 malaria 3 4 Sam Salman, Madhu Page-Sharp, Susan Griffin, Kaye Kose, Peter M. Siba, Kenneth F. 5 Ilett, Ivo Mueller, Timothy M. E. Davis 6 7 School of Medicine and Pharmacology, University of Western Australia, Fremantle 8 Hospital, Fremantle, Western Aust...
متن کاملArtemisinin-Naphthoquine versus Artemether-Lumefantrine for Uncomplicated Malaria in Papua New Guinean Children: An Open-Label Randomized Trial
BACKGROUND Artemisinin combination therapies (ACTs) with broad efficacy are needed where multiple Plasmodium species are transmitted, especially in children, who bear the brunt of infection in endemic areas. In Papua New Guinea (PNG), artemether-lumefantrine is the first-line treatment for uncomplicated malaria, but it has limited efficacy against P. vivax. Artemisinin-naphthoquine should have ...
متن کاملIntramuscular artemether in female patients with uncomplicated falciparum malaria.
Thirty-three female patients suffering from acute uncomplicated falciparum malaria were treated with intramuscular artemether for 5 days during May-October 1990. Fourteen patients received 160 mg as an initial dose, followed by 80 mg daily for 4 days. Nineteen patients with low body weight (mean weight of 36.5 kg) were given artemether at 3.2/kg as a loading dose and followed by 1.6 mg/kg/dose ...
متن کاملCase Report of a Pituitary Macroadenoma Treated With Artemether Artemether and Pituitary Macroadenoma
with radiation) is the most common treatment option. Treatment of adenomas with surgery alone is associated with a 9% risk of significant complications other than hypothyroidism. Additionally, there is a significant recurrence risk with surgical treatment alone. Park et al found a 5-year recurrence rate of 15.2% and a 10-year recurrence rate of 50.5% for 132 patients having nonfunctioning macro...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2011
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00375-11